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First, clean the blister with an antiseptic wipe.
Sterilize the point of a safety pin, needle, or knife with flame or an alcohol swab. Gently pierce the blister, then massage the fluid out. Leave the skin that covers the blister intact.
Cut a donut-shaped piece of moleskin to fit over the blister. Alternately, you can cover the blister with a friction-reducing dressing, such as Blist-o-Ban.
Prevent infection by filling the hole in the moleskin with antibiotic ointment.
Secure the moleskin with athletic or duct tape.