The deepest part of the Deep South comes alive on this 40-mile path as it follows its namesake drainage through a coastal floodplain riddled with oxbow lakes and dense stands of sweet gum, loblolly pine, bald cypress, and maple trees. Ninety bridges span the watery route, but you'll still get your boots wet. An especially scenic section of the trail is the 10 miles through the 5,000-acre Black Creek Wilderness.
Contact: Black Creek Ranger District, DeSoto National Forest, (601) 928-4422; www.fs.fed.us/r8/miss.
Location: 30.9939443, -89.0509701